We’re proud to announce the publication of our latest research in ACS Electrochemistry. This work was performed in partnership between the University of Galway and DirectSens Biosensors GmbH
“An oxygen-insensitive electrochemical biosensor for L-lactate using a novel FMN-dependent lactate dehydrogenase”
Reshma Kidayaveettil*, Christopher Schulz° , Alfons K. G. Felice°, Leander Suetzl° & Dónal Leech* °DirectSens Biosensors GmbH, *University of Galway
Breaking the Limits of L-Lactate Sensing
L-lactate is an important biomarker in medicine, biotechnology, and food quality control. However, conventional biosensors based on lactate oxidase (LOx) or NAD⁺-dependent LDHs are hampered by oxygen interference and unstable cofactors limiting stability, especially in continuous applications. This study presents a new oxygen-insensitive biosensor built around a novel FMN-dependent lactate dehydrogenase (LactaZyme® LDHLt) combined with an osmium redox polymer mediator.
Key Highlights
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Oxygen-independent: Only ~2% signal loss under oxygen saturation (vs. ~25% for LOx).
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High sensitivity: 0.16 mA cm⁻² mM⁻¹ with strong electrocatalytic performance.
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Robust & versatile: Stable across a wide pH and temperature range.
Why It Matters
This work establishes LDHLt-based biosensors as a reliable and practical platform for lactate detection in complex samples — paving the way for robust diagnostics also when long term continuous measurement is required.
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